Computational knowledge integration in biopharmaceutical research

Computational knowledge integration in biopharmaceutical research

An initiative to increase biopharmaceutical research productivity by capturing, sharing and computationally integrating proprietary scientific discoveries with public knowledge is described. This initiative involves both organisational process change and multiple interoperating software systems. The software components rely on mutually supporting integration techniques. These include a richly s...

Constructive Research and Info-Computational Knowledge Generation

It is usual when writing on research methodology in dissertations and thesis work within Software Engineering to refer to Empirical Methods, Grounded Theory and Action Research. Analysis of Constructive Research Methods which are fundamental for all knowledge production and especially for concept formation, modeling and the use of artifacts is seldom given, so the relevant first-hand knowledge ...

Practical Data Integration in Biopharmaceutical R&D: Strategies and Technologies

Vertical Integration of Disposables in Biopharmaceutical Drug Substance Manufacturing

level: interMediAte S ingle-use (disposable) technologies are gaining significant traction in biopharmaceutical manufacturing due to reductions in capital investment for plant construction, lower requirements for cleaning and sterilization, and the advantages of eliminating crosscontamination during multiproduct manufacturing (1–4). In the early days of disposables, single-use (SU) systems were...

Virtual Reality Integration Techniques in Computational Materials Research

We recently presented a framework for virtual reality integration into modern computational research techniques. We developed an environment in which one could theoretically view simulations of electron transfer in cytochrome proteins. Here, we actually implemented the simulation using the kinetic Monte Carlo method into the Unity Game Engine, allowing for immersive real-time rendering and mani...